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Chronic inflammation is sustained by a lack of Notch signaling leading to toll-like receptor stimulation with subsequent TNF- and IL-1 secretion causing dendritic cell activation and IL-23 release which polarizes Th17 cells and leads to increased IL-17

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That structural narrowness is the entire premise behind AOD-9604 as a research compound: a peptide that retains one specific signaling function of growth hormone without carrying its broader hormonal footprint