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Pathogenesis of Diabetic Gastroparesis There are multiple mechanisms linking diabetes to gastric motor dysfunction, such as autonomic neuropathy, enteric neuropathy involving excitatory and inhibitory nerves, abnormalities of ICC [54] (Table 3), acute fluctuations in blood glucose, incretin-based medications used to normalize postprandial blood glucose (Table 5) and perhaps psychosomatic factors via autonomic mechanisms

Iakova, P., Awad, S

Current therapeutic strategies for T2DM management prioritize metformin as the first-line pharmacological intervention, primarily through its dual mechanisms of suppressing hepatic gluconeogenesis and enhancing peripheral glucose utilization in skeletal muscle tissue 3,4

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