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the first and second cysteines are disulfide bonded to each other because they were available first during protein translation

Studies of patients with Hashimotos thyroiditis and subclinical hypothyroidism showed that supplementation of Myo and selenomethionine significantly decreased TSH, TPOAb, and TGAb concentrations, while simultaneously increasing thyroid hormones levels and restoring euthyroid state in patients with autoimmune thyroiditis (203, 204)