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Patients may gradually return to previous eating patterns, including consumption of high-calorie foods, frequent snacking, or inadequate physical activity

Furthermore, GLP-1 receptor agonists allow greater treatment customization based on individual patient's disease progression and therapeutic response

(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice