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Gastrointestinal side effects are the most commonly reported adverse effects of tirzepatide, with clinical trials showing dose-dependent rates: nausea (20-33%), diarrhea (12-23%), vomiting (9-16%), constipation (11-17%), and abdominal pain

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Many users recommend refrigerating their supplements before taking them, as colder temperatures can dull the taste buds' sensitivity

Patients and prescribers should verify current FDA guidance, as this is an actively changing area