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Key search concepts included *Ganoderma lucidum* polysaccharides, diabetes mellitus, inflammatory responses, programmed cell death (apoptosis), insulin resistance and sensitivity, oxidative damage, pancreatic islet function, glycolipid homeostasis, gut microbiota modulation, multimodal or integrative therapies, structural or formulation advancements, diabetic nephropathy, hepatotoxicity, cardiovascular complications, chronic non-healing diabetic ulcers, neurodegenerative and neuropathic manifestations, and diabetic retinopathy

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Kinetic data were analysed in Excel and SigmaPlot 12 by non-linear and linear regression according to MichaelisMenten, LineweaverBurk, EadieHofstee and Hanes theory 11,12,18