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The tablet must be taken on an empty stomach, with no more than 4 oz of plain water, and at least 30 minutes before any food, beverage, or other oral medications

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However, this decision has placed anesthesiologists at odds with gastroenterologists performing endoscopic procedures, who maintain that there is sparse available evidence to back claims of potential complications and that this overly conservative measure will only disrupt patient care

And its a history with its share of ignominy: In the mid-1990s, a drug that combined fenfluramine and phentermine, known as fen-phen, exploded in popularity after a single, 121-patient study showed it was effective for weight loss