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CJC-1295 and Somatotroph Biology The GHRH-receptor signalling pathway activated by CJC-1295 stimulates adenylate cyclase, increasing intracellular cAMP and engaging PKA-linked transcriptional regulation of the GH gene in somatotroph cells with in vivo research confirming increased pituitary RNA, GH mRNA, and somatotroph cell number following administration, establishing that GHRH-class secretagogues act on multiple levels of GH axis biology beyond simple acute secretion
(2011) 6:e25792
Alterations in the Expression of Signal-Transducing CD3 Zeta Chain in T Cells From Patients With Chronic Inflammatory/Autoimmune Diseases
De Maeyer RPH, Chambers ES
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