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Gender also seems to play a role with more prevalence of the disease among the females than the males in the developing nations indicating that societal norms may also play a role

These GLP-1R + cells were often accompanied by high expression of Foxp3 and CD25 and low expression of IL-7R (CD127), which were characteristic protein markers of Treg cells

52 Cellular stress, such as DNA damage, hypoxia, and oncogene activation, disturbs the interaction between p53 and MDM2 and inhibits p53 degradation, resulting in p53 accumulation