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Adding human umbilical vein endothelial cells (HUVECs) to apical-out (AO) hormone-responsive endometrial organoids (that replicate the natural orientation of endometrial epithelial cells), organoids self-organized to form an integrated endothelial network [87]

The nuclear morphology of the cells was studied using the cell-permeable DNA-specific dye Hoechst 33342

A 2026 analysis in the Journal of Medical Internet Research found real-world discontinuation rates far exceed clinical trial numbers, with up to 70% of patients stopping treatment within 24 months -- often because of these effects

2024;109(3):e1267e79