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Alongside the enhancing hepatic insulin/AKT signaling, PDK4 inhibition also activates the lipid AMPK/FOXO1/CD36 regulatory axis to promote liver regeneration by increasing fatty acid uptake

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Loree JM, Wang Y, Syed MA, Sorokin AV, Coker O, Xiu J, Weinberg BA, VanderWalde AM, Tesfaye A, Raymond VM, Miron B, Tarcic G, Zelichov O, Broaddus RR, Ng PKS, Jeong KJ, Tsang YH, Mills GB, Overman MJ, Grothey A, Marshall JL, Kopetz S

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