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To further support the impact of CBS on replenishing GSH levels under cystine-restricted conditions, we expressed a codon-optimized CBS (CBS OPT ), which is resistant to the designed sgRNA (Fig

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dahliae -infection SA levels massively increased in transgenic plants but H 2 O 2 accumulation was low as compared to wild type plants, indicating that GST may regulate the content of ROS via catalytic reduction with GSH that affects also the SA content (Gong et al., 2018)

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