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Dahl K, Brooks A, Almazedi F, et al

Supply Chain Vulnerability and Climate Sensitivity Yerba mate cultivation is concentrated in specific subtropical regions of South America, primarily Argentina, Paraguay, and Brazil, which creates inherent supply chain concentration risk

Additionally, SGLT2i can lower HbA1c levels by 0.5-1.0% and support weight loss ( Studies have indicated that increased expression of the sodium-hydrogen exchanger isoform 1 (NHE-1) is linked to heart failure and may contribute to the development of hypertrophy and cardiac injury during ischemia and reperfusion ( Of note, long-term use of SGLT2i may lead to a reduction in glycosuric efficacy, without a corresponding decline in cardiovascular benefits