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On the contrary, activation of the TSS pathway under physiological cystine supplement is achieved under DMF treatment through enhanced CBS expression and cystine uptake to protect against ferroptosis in SCD erythroblasts
Yin, Y., Li, Y., & Zhang, W
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In one, multi-clinic, placebo-controlled study employing an add-on design (adjunctive therapy), 144 patients who continued to suffer eight or more CPS per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the "therapeutic range" were randomized to receive, in addition to their original antiepilepsy drug (AED), either divalproex sodium or placebo
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