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At 24 weeks, the mean change body weight was 7.2% with 1 mg, 11.8% with 4 mg (starting with 2 mg), 13.9% with 4 mg (starting with 4 mg), 16.7% with 8 mg (starting with 2 mg), 17.9% with 8 mg (starting with 4 mg), and 17.5% with 12 mg (starting with 2 mg), compared to 1.6% in the placebo group [38]

Additionally, the guidelines state that experts do not recommend combining products, noting that levothyroxine (the ingredient in Synthroid) alone is the preferred treatment for hypothyroidism

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