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References Kruse T, Hansen JL, Dahl K, Schffer L, Sensfuss U, et al

Controlled human studies have identified side effects consistent with gastrointestinal tolerability patterns associated with both amylin analogs and GLP-1 receptor agonists

After equilibration, the straws were placed in a programmable freezer (Freeze Control, Cryologic, Australia) pre-cooled to 5 C, the temperature was lowered from room temperature to 80 C at a rate of 12 C per min, after which the straws were plunged into liquid nitrogen for long-term storage

The key point: the best option depends on the reason for low B12 and your clinical context