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Inhibition of system Xc (inhibiting SLC7A11 expression) influences the GSH synthesis, which decreases GPX4 activity and ultimately triggers ferroptosis

In the SOUL trial, published in March 2025 in the New England Journal of Medicine , researchers studied 9,650 participants aged 50 and older with type 2 diabetes and either cardiovascular or kidney disease

Replicates, randomization and blinding In vivo studies were performed in male or female age-matched mice that were randomly distributed to achieve groups of equal body weight and body composition

What to expect from TRT, BHRT, GLP-1, and peptides and how we monitor it