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According to the American Society for Metabolic and Bariatric Surgery, surgical patients lose up to five times more weight at two years compared to those using semaglutide or tirzepatide, with sustained benefits for a decade or more, whereas most medication users regain weight once treatment stops

They started tirzepatide six months ago and only now notice increased shedding, so they blame stress, seasonal changes, or aging instead of recognizing the medication-triggered pattern

Some lost less, and some even gained weight, as much as maybe 40 pounds (18 kg), even after continuing to inject the drug for years

GLP-1 receptor agonists have become increasingly popular, and its easy to see why