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When the formulation includes B6, the pyridoxine is typically already incorporated into the lyophilized powder or provided as a pre-mixed solution

Additionally, receptor expression may dynamically change during treatment (e.g., upregulation or downregulation in response to therapy), further impacting the long-term reliability of active targeting NPs

The concentration differences of metabolites in tumor cells and the tumor microenvironment can significantly affect the proliferation, migration, and drug resistance of tumor cells [1], as well as the immune response of immune cells in the microenvironment [11, 12]

In Phase 2 trials, diarrhoea affected approximately 3040% of participants and nausea up to 60%