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The agency cleared Entresto despite missing the mark in its phase 3 trial, because there is such a desperate need for drug therapies that can improve the prospects for people with HFpEF.

Very common side effects include [4, 5]: Liraglutide: Nausea Diarrhoea Constipation Headache Fatigue Semaglutide: Nausea Vomiting Constipation Abdominal pain Headache Fatigue Serious side effects of both medications may include severe abdominal pain which could be a sign of pancreatitis, gallbladder problems, or very low blood sugar (especially in people also taking diabetes medications)

Therefore, FXR not only plays an important regulatory role in lipid metabolism but is also a key transcription factor in glucose homoeostasis (Reference Kim and Fang27,Reference Pathak, Xie and Nichols28)