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Beyond glucose-lowering, tirzepatide achieved remarkable and sustained weight loss, with mean reductions exceeding 20% in non-diabetic adults with obesity after 72 weeks

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Intestinal and brain cells contain prohormone convertase 1 (PC1), which is able to cleave proglucagon into Glicentin, Oxyntomodulin, GLP-1, GLP-2 and IP-2, while pancreatic islet cells contain prohormone convertase 2 (PC2), which capable of cleaving proglucagon into Glucagon and MPGF

Pretreatment with each examined GLP-1 analogs, including GLP-1(736), liraglutide, and exendin-4, led to significantly reduced Ca 2+ responses (by 53.8%, 58.1%, and 72.2%, respectively)