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These figures are broadly comparable, though the glucagon receptor activity in retatrutide theoretically raises concern about hepatic glucose output during dose titration

Mouse studies All in vivo experiments were conducted according to international principles of animal care and under the approval of the Danish Ethical Committee for Animal Research and the Danish Animal Experimentation Inspectorate

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Impact of a weekly Glucagon-Like peptide 1 receptor agonist, albiglutide, on glycemic control and on reducing prandial insulin use in Type 2 diabetes inadequately controlled on multiple insulin therapy: a randomized trial