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Individuals with a History of Gastrointestinal Issues GLP-1 medications are known for causing nausea, vomiting, diarrhea, and constipationespecially during dose escalation

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Plant sterol esters from -linolenic acid activate SIRT1, downregulating NLRP3 and ASC expression, reducing colocalization with cleaved caspase-1, and lowering GSDMD cleavage, thereby inhibiting hepatocyte pyroptosis and slowing MASH progression in mice