BIODEGRADES IN DAYS NOT DECADES
Based on the k d (fractional turnover rate) value of 0.0133/day for the loss of intramuscular carnosine at the physiological steady state (Spelnikov and Harris 2019), the intramuscular concentrations of carnosine in women and men (17.5 and 21.3 mmol/kg dry weight, respectively), skeletal muscle mass (45% of BW), and its dry matter content (30%), it can be estimated that a 60-kg woman and a 70-kg man synthesizes 427 and 606 mg carnosine per day, respectively
There becomes an increased peristalsis of the bowel, which in turn leads to secretion of large volumes of electrolyte-rich fluid into the bowel (often termed third spacing)
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