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Interestingly, Gro3P accumulation caused by loss of solute carrier transporter SLC25A13, which leads to Citrin deficiency, was found to directly activate the transcription factor ChREBP to induce expression of fibroblast growth factor 21 (FGF21), which modulates food and alcohol preferences in the brain and contributes to metabolic dysfunction-associated steatotic liver disease (MASLD)[formerly known as non-alcoholic fatty liver disease (NAFLD)] 19

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PMID: 20805887 Ambroziak U, Hybsier S, Shahnazaryan U, Krasnodbska-Kiljaska M, Rijntjes E, Bartoszewicz Z et al

In the case of muscle-specific IR, mitochondrial dysfunction is characterized by metabolic abnormalities and diminished oxidative phosphorylation, decreased electron transport chain activity, and low expression levels of PGC1, a master transcriptional regulator of mitochondrial biogenesis [79]