Here we provide an overview of irAEs for current ICIs and their management, aligned with the NCCN Guidelines: Management of ImmunotherapyRelated Toxicities (Version 1.2025), and the Society for Immunotherapy of Cancer (SITC) clinical practice guideline on ICIrelated adverse events (Rapid Update v1.2, published 2024)
The persistent accumulation of ROSarising from endogenous sources (e.g., mitochondrial leakage, enzymatic reactions) and exogenous insults (e.g., ultraviolet radiation, pollutants, tobacco)can overwhelm the antioxidant defense threshold, triggering widespread oxidative damage targeting proteins, lipids, and nucleic acids
Chemiluminescence is a very interesting way to evaluate an oxidative stress and lipid peroxidation in biological samples and living systems
Take them 30 to 60 minutes before bed