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10.1126/science.1135901 40 ItoS.KinoshitaS.ShiraishiN.NakagawaS.SekineS.FujimoriT.et al (2000)

Lyophilized semaglutide , a revolutionary medication for diabetes management and weight loss, requires specific storage conditions to maintain its efficacy and safety

Binge eating, not followed by recurrent use of inappropriate compensatory behaviors, often results in weight gain, and for this reason, some individuals make several attempts to lose weight

Such heterogeneity is consistent with the large total levels of heterogeneity (I = 99.21%), indicating large differences among studies in terms of design, population of the study, types of GLP-1 RAs, or duration of treatment