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However, most REES-based studies of IDPs were conducted very recently and therefore did not contribute to the establishing of the IDP field [for example, REES was used for analysis of -synuclein and amyloidogenic k-casein in 2013 and 2014, respectively (Jain et al., 2013

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These findings align with broader systematic reviews and meta-analyses which suggest that while IA PRP and HA may offer symptomatic relief in early-stage OA, their impact on disease progression, cartilage regeneration, or long-term pain control remains questionable