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Estrogen has been linked to increased activation of CD4 T cells and higher expression of pro-inflammatory cytokines IL-1 and IFN-, which may allow women to more effectively combat viral infections including COVID-19

In addition, the UBX7-p97-UFD1/NPL4 complex, consisting of a ubiquitin-targeted ATP-dependent segregase, p97, and two heterodimeric cofactors, UBX7 and UFD1/NPL4, extracts ubiquitinated NRF2 from the KEAP1-NRF2 complex and transfers it to the 26S proteasome for its degradation [154] (Fig

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