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While the RDA is 2.6 mcg, studies show that higher doses of up to 1,000 mcg (1 mg) daily are generally considered safe during pregnancy, especially when treating deficiency [*]

B12 injections are most appropriate for people with confirmed or suspected B12 deficiency

Freezing is even worse because ice crystals physically damage the peptide structure, causing irreversible denaturation

Last reviewed: May 30, 2026 Last updated: May 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations