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They include: Bromazolam and flubromazolam, also known as designer benzodiazepines, a class of sedative drugs Nitazenes, a class of ultra-potent synthetic opioidsincluding isotonitazenelinked to overdose deaths Tianeptine, an atypical antidepressant with opioid-like effects and often called gas station heroin Phenibut, a sedative supplement that acts on the brain's GABA system, which helps regulate anxiety and calm Connecticut banned all of these substances along with kratom in 2026

For example, Eli Lilly's Zepbound is gaining adoption for obesity management while supporting broader cardiometabolic treatment strategies