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Researchers found that those in the treatment group had a greater decrease in kidney function and an increase in vascular events, including heart attack and stroke

doi:10.5021/ad.2016.28.4.438

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Tirzepatide (Mounjaro for diabetes, Zepbound for weight loss) activates two receptors GLP-1 and GIP which is why it tends to produce somewhat stronger weight-loss results on average