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In mice, obesity and the associated visceral adipose tissue inflammation result in insulin resistance, a process which appears to be mediated via increased synthesis and release of hepatic DPP-4, since eliminating hepatocyte Dpp4 expression suppresses inflammation and improves insulin sensitivity (82, 83)

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The Evergreening Strategy: Extending Exclusivity Beyond 2026 Evergreening is a tactic where pharmaceutical companies secure additional patents on minor modifications or new uses of an existing drug, delaying generic competition