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Common Side Effects of Tirzepatide and Semaglutide The most frequently reported side effects include: Nausea (particularly during dose increases) Diarrhea or constipation Vomiting Abdominal discomfort Decreased appetite (expected effect) Most side effects occur during dose escalation and typically improve within 4-8 weeks as your body adjusts to the medication

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10.1016/s0301-0082(99)00060-x 41 DuanJ.-Y.LinX.XuF.ShanS.-K.GuoB.LiF.-X.-Z.et al (2021)