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Bordone strongly recommends GLP-1s for patients with psoriasis if these conditions apply: A BMI over 30 A BMI over 27 with obstructive sleep apnea High blood pressure Abnormal cholesterol High fasting glucose Insulin resistance Prediabetes Ive seen firsthand how these medications can positively impact patients who have both psoriasis and metabolic conditions like obesity or type 2 diabetes, says Kopelman, who coordinates with her patients primary care providers when she feels a GLP-1 may help

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If you are losing fat at a satisfactory rate on 8mg while maintaining adequate protein and training performance, there is no compelling reason to increase further

Large trials show fewer heart attacks and strokes with GLP-1 use through improved endothelial function, reduced oxidative stress, and better nitric oxide availability. If other benefits manifest at lower doses, cardiovascular protection likely does too