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A prospective, observational, multicenter study was conducted in more than 40,000 Chinese adults with knee osteoarthritis and type 2 diabetes mellitus [22]

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Typical semaglutide escalation follows a pattern: 0.25 mg for weeks 1 through 4, then 0.5 mg for weeks 5 through 8, then gradual increases toward the target dose of 1.0 to 2.4 mg depending on response and tolerance