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Potential Research Applications: Telomerase activation and cellular longevity studies Anti-aging and pineal gland function research Circadian rhythm and melatonin regulation studies DNA repair and oxidative stress resistance models For laboratory research only

4.1 Re-evaluating therapeutic approaches in AD For years, the amyloid cascade hypothesis has been the dominant framework guiding AD research

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Here, we demonstrate that the GST tag is a substrate of transglutaminase 2 (TG2), which is a calcium-dependent enzyme that polyaminates or crosslinks substrate proteins