Those answers matter more than a chart copied from the internet
FIGURE 4 3 Therapeutic effects of bioactive metabolites in DKD Natural active substances such as polyphenolic metabolites, peptides, polysaccharides, flavonoids, and so on, originate from nature, and have the advantages of high safety, multi-targeted action, abundant resources, and sustainable utilization, which show a great potential for the treatment of DKD (Mitra et al., 2025
However, one can have a normal amount of mast cells produced in the bone marrow but, due to a combination of genetic predisposition and exposure to triggers, mast cells will become overactivated, leading to a condition known as Mast Cell Activation Syndrome (MCAS)
This data points to IL-9 as a potential mediator or target of the IL-23/Th17 pathway suppressor (Witte et al