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SKU: 84353698528

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Slow titration schedules reduce side effect intensity compared to rapid dose escalation

Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu

Second, many clinical trials are of relatively short duration (often 6 months), failing to capture the long-term efficacy and sustainability of interventions on OA progression, a inherently chronic disease