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From a public health perspective, the results underscore the continued importance of population-level investments and policy in promoting healthy diet, physical activity, sleep, stress management, and social connection, even in a modern drug era, he said

This shift acknowledges that obesity is a complex, chronic disease-not a matter of willpower-and requires a sophisticated medical approach

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The choice between medications should rest primarily on efficacy data, tolerability, availability, and cost rather than the B12 inclusion, which is valuable in both formulations