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Approximately 90% of glutathione is stored intracellularly, making oral supplementation challenging due to bioavailability limits

To move Epitalon from experimental to evidence-based, several developments are essential: Randomized, double-blind, placebo-controlled clinical trials, ideally targeting specific endpoints (sleep, immune aging, telomere attrition) Toxicology and long-term safety studies, including exploration of stereoisomer effects and off-target consequences Validated delivery systems (e.g., dendrimer-conjugates, transdermal patches) that make real-world use feasible Pharmacodynamic biomarkers, to identify responders and track efficacy objectively over time Epitalon is not snake oil, but its also not a magic bullet

doi: 10.1161/CIRCGENETICS.113.000321 113 ShenG.LiL.WangQ

L-citrulline has been shown to increase NO and vasoactivity [7] and potentially up-regulate MPS [8]