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Science 309, 409415

Studies have shown that in sperm from diabetic patients, increased acetylation levels of H3K9 and H3K14 lead to abnormal open chromatin structures associated with gene promoter regions, ultimately interfering with the expression of genes required for spermatogenesis [194, 195]

Signal Transduct Target Ther 8(1):435 Acknowledgements We sincerely appreciated BioRender ( for the construction of our figures

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