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The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway

Mice received a single intraperitoneal injection of either 3 mg/kg psilocybin or isotonic saline

Successful clinical validation would not only provide a new treatment option but also retrospectively validate the CXXC5-targeting mechanism in humans, which would increase confidence in PTD-DBM as well

Patients with significant bile acid diarrhea, severe pancreatic insufficiency, or active pancreatitis may face higher risk and warrant closer monitoring or alternative strategies