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Thus, the deficient insulin signaling, named brain insulin resistance, has become a rationale for using intranasal insulin therapy to treat AD and mild cognitive impairment in clinical trials (Craft et al., 2012)

Thirteen years from animal model to randomized controlled trial is actually fast, by addiction medicine standards

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While peptides are generally well tolerated because they break down into naturally occurring amino acids, the potential for sensitization exists with any foreign substance applied to immunologically active eczema skin