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Individuals who have received radiation therapy as a treatment for medical conditions, such as Hodgkins lymphoma or head and neck cancers, face an elevated likelihood of PTC occurrence ( 4 Warburg effectthe novel target in PTC clinical management Literature data has indicated that molecular alterations within signaling pathways, such as RAS, RAF, and mitogen-activated protein kinase (MAPK), play a role in the development of thyroid neoplasms (Soares et al., 2003)

Phagocytic leucocytes (white blood cells) especially neutrophils produce abundant of oxygen radicals through NADPH-Oxidase activity (O2 + e O2) as effort to destroy invading pathogens in defense or protection of the host organism.11 Oxygen-derived radicals are also produced as integral metabolites in cascades of enzyme catalyzed reactions