Thanks to their expanded interface with the target protein, peptide PROTACs demonstrate superior potency, higher selectivity, and reduced toxicity compared to low molecular weight compounds, especially when targeting proteins lacking well-defined binding pockets (Kargbo, 2019)
/ Bourgeois et al
Tesofensine side effects can include dry mouth, difficulty sleeping, anxious feelings, increased blood pressure, and serotonin syndrome (if combined with antidepressant medication.) Who should NOT use Tesofensine
However, I have strong reservations and concerns about self-injection of non-FDA-approved or compounded peptides that carry significant risks, including contamination, dosing errors and serious adverse events such as compartment syndrome (dangerous muscle pressure buildup) that can lead to surgery or even death, as documented by FDA reports