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However, the authors note that the certainty of evidence was low

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Cosmos Study October 14, 2025 Dual-Team Study Team A:Kersten Bartelt, RNEric Barkley Team B:Joel Jones, PharmDJoe Deckert, PhD Key Findings Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide