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however, human studies have not revealed significant abnormalities with first-trimester exposure

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Physiologia plantarum, 1994, 13 1: 696-717

[19] [21] Typical adult doses for the treatment of vitamin C deficiency range from 200 mg to 1 g daily, administered intravenously, with higher doses (up to 100 grams per day) reserved for specific clinical protocols under close supervision