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To bridge the gap between patients in RCTs and those in the clinic, RCTs should be complemented with real-world observational studies using regional/national COPD databases

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Abbreviations ALA: Alpha-linolenic acid ICHD-3: International Classification of Headache Disorders-3 VAS: Visual analog scale MI: Migraine index HDR: Headache diary result MHIS: Migraine headache index score DASS-21: 21-Item Depression, Anxiety, and Stress Scale HIT-6: Headache Impact Test-6 MSQ: Migraine-Specific Quality of Life BMI: Body mass index IPAQ: International Physical Activity Questionnaire MET/h/day: Metabolic equivalent hours per day ANCOVA: Analysis of covariance ITT: Intention-to-treat LOCF: Last observation carried forward NSAIDs: Non-steroidal anti-inflammatory drugs PUFAs: Polyunsaturated fatty acids MUFA: Monounsaturated fatty acid CoQ10: Coenzyme Q10 HIS: International Headache Society References Steiner TJ, Stovner LJ

In her practice, Dushay has seen some patients develop or exacerbate eating disorders while taking the medications