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These recommendations are very consistent with the key points from the most current international guidelines, especially those published, in 2024 and 2025, by multi-society groups in both the US and the UK 1-3

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The outcome of Carney Complex depends upon the location and type of tumors and the combination of signs and symptoms Additional and Relevant Useful Information for Psammomatous Melanotic Schwannoma: From a biopsy specimen, it is very hard to differentiate between a benign or malignant Psammomatous Melanotic Schwannoma, and hence, work-up of the patient for metastasis is very important.

doi:10.1097/GCO.0000000000001015 Graczyk NA, Bisschops J